information of hereditary-affected hair loss
Causes
of hair loss
Hair
loss is caused by 5-Alpha reductase enzyme reacting with testosterone secreted
from the prostate and steroid hormones. Dihydrotestosterone (DHT) is a leading cause
of the fat accumulated on head skin and sebaceous glands attached to hair follicles.
DHT stimulates the enlargement of sebaceous glands and fat accumulation,
resulted in the clogged capillaries nourishing the follicles and the blood
carrying less nutrients and oxygen to cells. In addition, the fat inhibits the normal
hair formation process and resulted that new hair replacing old hair becomes
smaller and smaller, and eventually leading to hair loss and baldness and just
the vellus hair is left.
5
alpha-reductase enzymes are commonly found in the
prostate, testes, hair follicles, and adrenal glands. This enzyme achieves the transformation
of the testosterone into dihydrotestosterone [reductase enzyme synthesis of
DHT]
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§ The
insertion of the sebaceous glands into the hair shaft
§ The
insertion of the sebaceous glands in the hair shaft
§ Medical
treatment approach
1. Reductase
is inhibited by drug (MK-906, Proscar and Propecia, synthetic drug used to
treat prostate cancer and male pattern baldness (MPB), Type II. Reductase enzyme achieves the transformation
of the testosterone into dihydrotestosterone (DHT).
2. Minoxidil
is a vasodilator which is responsible for dilating blood vessels and opening
potassium channels that allow more oxygen to blood and nutrients to the hair
follicles. This can cause pores in Telogen phase, which is secreted and then
replaced by new thicker hairs in Anagen phase. Minoxidil is an antihypertensive
drug and dilating blood vessel. It is composed of the nitric oxide.
Minoxidil
is less effective with a presence of the large areas of hair loss. In addition,
the effectiveness is largely demonstrated in younger men whose experience of hair
loss is less than 5 years.
3. Follicular
Unit Transplantation (FUT) is a hair restoration technique for patients with
fat (oil) glands, nerves, small muscles, and sometimes vellus.
FOLLICULAR
UNIT EXTRACTION (FUE / FIT) in hair transplant
Follicular
Unit Extraction or known as “FUE” or “FIT” is a new way of hair transplant; each
unit of follicular hair is pulled using the small instrument.
Follicular
unit extraction procedures
Two
months after the follicular unit extraction
Eight months after the follicular unit
extraction
Unit
of follicular hair is pulled out of the scalp by using the extractor with small
diameter.
Follicular
unit extraction prepared for hair transplantation and
restoration
Results
of follicular unit extraction
Before
After
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